Role of Mesenchymal Stem Cell Therapy on Healing of Corneal Wound Induced by Alkali Burn in Rats

Background: Chemical injury is the common cause of corneal damage. Alkali exposure cause defective clarity and impaired vision with lack of satisfactory therapy. Bone marrow mesenchymal stem cells (BM-MSCs) are multipotent self-renewal cells and they give a hope for better treatment of many diseases.

Aim of the Review: This review aimed to show the role of subconjunctival administered BM-MSCs therapy on alkali-induced corneal burn in rats, and its effect on the damaged corneal epithelium and the area of corneal neovascularization (CNV).

Conclusion: Subconjunctival injection of MSC transplantation could accelerate corneal wound healing attenuates inflammation and reduces CNV in alkaline-burned corneas.