Association of cerebral spinal fluid copper imbalance in amyotrophic lateral sclerosis

Chen, Qiao Yi and Wu, Peng and Wen, Ting and Qin, Xing and Zhang, Ronghua and Jia, Rui and Jin, Jiaoting and Hu, Fangfang and Xie, Xiaoge and Dang, Jingxia (2022) Association of cerebral spinal fluid copper imbalance in amyotrophic lateral sclerosis. Frontiers in Aging Neuroscience, 14. ISSN 1663-4365

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Abstract

A plethora of environmental risk factors has been persistently implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS), including metal/metalloids. This study aimed to examine potential associations between cerebral spinal fluid (CSF) metal/metalloids and ALS risks. CSF concentrations of copper (Cu), nickel (Ni), mercury (Hg), arsenic (As), manganese (Mn), and iron (Fe) in ALS (spinal- and bulbar-onset) patients and controls were measured using inductively coupled plasma mass spectrometry (ICP-MS). Results from this study revealed marked differences between control, spinal-onset, and bulbar-onset groups. We report that Cu levels were lower in the ALS and spinal-onset groups compared to the control group. Ni level were higher in the spinal-onset group compared to the control and bulbar-onset groups. In addition, associations between CSF metal/metalloid levels with disease severity, sex, and serum triglycerides were also examined to broach the potential relevance of neurotoxic metal/metalloids in ALS disease heterogeneity.

Item Type: Article
Subjects: Archive Digital > Medical Science
Depositing User: Unnamed user with email support@archivedigit.com
Date Deposited: 18 Oct 2023 05:19
Last Modified: 18 Oct 2023 05:19
URI: http://eprints.ditdo.in/id/eprint/1410

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