EFFECT OF KETAMINE HYDROCHLORIDE ON OVARIAN AND UTERINE ACTIVITIES IN ALBINO RATS

Ketamine hydrochloride at the dose levels of 1mg and 3mg/100 g body weight was administered to normal cycling rat for 20 days through intraperitoneal routes. At autopsy on 21st day significant reduction in the ovarian and uterine weight was observed. Histological observations showed decrease in the number and size of graafian follicles, corpora lutea and increase in the atretic follicles in the ovary. The uterus showed absence of endometrial glands, decrease in the height of myometrium, endometrium and its epithelial cells. The total protein and glycogen content of the ovary and uterus is decreased whereas the cholesterol content is increased. This action of ketamine hydrochloride to gonadotrophins is discussed.