PREVENTION OF Staphylococcus aureus CAUSING ECZEMA BY Glycyrrhiza glabra

Glycyrrhiza glabra is one of the therapeutic plants that show the adequacy for the disorder. Thus, the present study is an attempt to check the efficacy of G. glabra in the prevention and cure of eczema. “Phytochemicals” are non-nutritive compounds found or obtained from plants. It has been reported that Glycyrrhiza glabra plant extract is used to manage eczema, which has different phytochemical compounds. Eczema is caused by the causal organism, such as Staphylococcus aureus. Aspatate-semialdehyde-dehydrogenase is one of the key enzymes involved in its biochemical pathway. By using “Biovia Discovery Studio”, the “molecular docking of the phytochemicals” with the enzymes was studied. The strength of the interaction was evaluated based on “-CDOCKER energy and-CDOCKER interaction energy”. “High positive values for both the parameters indicated that out of different phytochemicals” 3-bromo-2-pentanol and liquiritigenin can effectively deactivate the aspatate-semialdehyde-dehydrogenase enzyme thereby interrupting the life cycle of S. aureus. The phytochemicals screening of the G. glabra root revealed the presence of alkaloids, glycocides, carbohydrates, starches, phenolic compounds, flavonoids, proteinsetc. The showed the memory enhancement, antimicrobial, anticancer activity. Many plants with their optional metabolites have a long history of use in current western medication and specific frameworks of customary medication and are the wellsprings of significant medications, such as “atropine, codeine, dioxin, morphine, quinine and vincristine and so on”. The utilization of home-grown medication in have created nations has extended forcefully in the last of the twentieth century. The pharmacological treatment of sickness started a while in the past with the utilization of herbs.