Research on Aloe vera Mucilage as Solubility Enhancer in Tablet Formulation

The present study is development of water insoluble compound into a sustained release matrix tablets
and the influence of aloe vera gel powder in the dissolution and other physical properties of the SR
matrix tablets were assessed. The HPMC and ethyl cellulose were used as polymer and different
concentration of aloe vera gel powder used as dissolution enhancer. Sustained release matrix tablets
were formulated by direct compression method and subjected to various quality control studies as per
the official pharmacopeial standards. The developed tablet formulation complies with the monograph.
The results suggest that aloe vera is improved the dissolution of curcumin. Dissolution kinetics
suggests that all the formulation followed Korsemayer Peppas model via anomalous diffusion
mechanism. To conclude the aloe vera gel powder can be used as dissolution enhancer for improving
the drug absorption of water insoluble drugs.