MICRORNA–RELATED GENE POLYMORPHISMS IN PATIENTS WITH RENAL DISEASE IN BABYLON PROVINCE

Micro Ribo Nucleic Acids (miRNAs) are endogenous short non-coding ribonucleic acid, its though (miRNAs) were controlled most of the necessary cellular processes by inhibiting gene expression through the post-transcriptional repression of their goal mRNAs. In kidneys, several types of research exhibited, that miRNA are related to nephritic development, homeostasis, and physiological functions. The study aimed to analyze the risk factor of MIR196A2 T>C (rs11614913) among patients with chronic and end-stage renal disease (ESRD).

The blood samples were collected from 100 patients divided into two groups, chronic renal disease (50 samples) and end-stage renal disease (50 samples), who admitted to Merjan Teaching Hospital in Babylon Province, Iraq. Additionally to healthy persons as a control group (50 samples), from February to July 2016. Genotyping of MicroRNA SNPs was performed using a polymerase chain reaction (PCR) technique, followed by Restriction Fragment Length Polymorphism. we tend to determined associate redoubled risk of just about twofold for ESRD and chronic compared to control, Continuous analysis unconcealed that the mutant genotypes of rs11614913 SNP are associated with the lowest overall survival compared with heterozygous and wild genotypes chronic and end-stage renal disease. The results of our study counsel that the variants specifically, rs11614913 of MicroRNA SNP may be concerned in status to chronic and ESRD.