EVALUATION OF VISUAL FIELD PARAMETERS OF GLAUCOMATOUS PATIENTS UNDER ORAL SUPPLEMENT BY FORSKOLIN, RUTIN AND VITAMINS B1 AND B2

Purpose: Forskolin, rutin and vitamins B1 and B2 are the main ingredients of a food supplement commercially available in Italy. This drug contributes to a small reduction of IOP in glaucomatous patients who are poorly responsive to multi-therapy treatment. The aim of this study is to report changes of visual field parameters after oral supplement of forskolin, rutin and vitamins B1 and B2.
Patients and Methods: This is a single center, retrospective study. It was conducted on files of 30 (13 M, 17 F) glaucomatous patients and 10 (4 M, 6 F) controls. All these patients were affected by open-angle glaucoma under monotherapy but this association was supplemented only once a day to 30 patients as long as 12 months. The ophthalmological data (IOP, pachymetry, visual field assessment by FDT 30-2 strategy mean deviation and pattern standard deviation) were checked at time 0, 6 months and 12 months from the beginning of the oral therapy.
The statistical analysis was performed by descriptive statistics, one-way ANOVA and Wilcoxon test. Results were considered significantly different when p<0.05.
Results: The two groups were age and sex-matched (p=0.335). The two groups were also matched as for pachymetry (p=0.187). The visual field parameters (mean deviation and pattern standard deviation by FDT 30-2 strategy) were statistically significantly different only at time 12 months (p=0.04).
Conclusion: This study stresses the neuroprotective effect of the association of forskolin, rutin and vitamins B1and B2 from a campimetric point of view.