MiRNA-Mediated Subpathway Identification and Network Module Analysis to Reveal Prognostic Markers in Human Pancreatic Cancer

Liu, Yuejuan and Cui, Yuxia and Bai, Xuefeng and Feng, Chenchen and Li, Meng and Han, Xiaole and Ai, Bo and Zhang, Jian and Li, Xuecang and Han, Junwei and Zhu, Jiang and Jiang, Yong and Pan, Qi and Wang, Fan and Xu, Mingcong and Li, Chunquan and Wang, Qiuyu (2020) MiRNA-Mediated Subpathway Identification and Network Module Analysis to Reveal Prognostic Markers in Human Pancreatic Cancer. Frontiers in Genetics, 11. ISSN 1664-8021

[thumbnail of pubmed-zip/versions/1/package-entries/fgene-11-606940/fgene-11-606940.pdf] Text
pubmed-zip/versions/1/package-entries/fgene-11-606940/fgene-11-606940.pdf - Published Version
Download (5MB)

Abstract

Background: Pancreatic cancer (PC) remains one of the most lethal cancers. In contrast to the steady increase in survival for most cancers, the 5-year survival remains low for PC patients.

Methods: We describe a new pipeline that can be used to identify prognostic molecular biomarkers by identifying miRNA-mediated subpathways associated with PC. These modules were then further extracted from a comprehensive miRNA-gene network (CMGN). An exhaustive survival analysis was performed to estimate the prognostic value of these modules.

Results: We identified 105 miRNA-mediated subpathways associated with PC. Two subpathways within the MAPK signaling and cell cycle pathways were found to be highly related to PC. Of the miRNA-mRNA modules extracted from CMGN, six modules showed good prognostic performance in both independent validated datasets.

Conclusions: Our study provides novel insight into the mechanisms of PC. We inferred that six miRNA-mRNA modules could serve as potential prognostic molecular biomarkers in PC based on the pipeline we proposed.

Item Type: Article
Subjects: Archive Digital > Medical Science
Depositing User: Unnamed user with email support@archivedigit.com
Date Deposited: 20 Jan 2023 04:58
Last Modified: 23 Dec 2023 08:31
URI: http://eprints.ditdo.in/id/eprint/90

Actions (login required)

View Item
View Item